In 2002, Anna Nicole signed with E! for her own show, aptly named The Anna Nicole Show. It became the network's highest-rated show after just one season and chronicled the over-the-top lives of Anna; her son; her assistant Kim Walther; her lawyer/BFF, Howard K Stern; and her dog, Sugar Pie. Think the So NoTORIous of five years ago. The show stayed on the air until 2004.

E! Studios' Jeff Shore said of Anna's private persona, "She was a sweet person who adored her son, made us laugh and cry with her and who was never afraid of what others may have thought of her."